Howard Hughes constructed the Hughes H-4 Hercules out of wood due to wartime limitations on the availability of aluminum. Nicknamed "The Spruce Goose," it took its brief maiden flight, with Hughes at the controls, in 1947. And never flew again.
After the first two taxi runs, four reporters left to file stories, but the remaining press stayed for the final test run of the day. After picking up speed on the channel facing Cabrillo Beach, the Hercules lifted off, remaining airborne at 70 ft (21 m) off the water at a speed of 135 miles per hour (217 km/h) for around a mile (1.6 km). At this altitude, the aircraft still experienced ground effect. Wikipedia
As tall as an A380, and with a wingspan greater than the mighty An-225 Mriya, it is the largest flying boat ever constructed, and has the greatest wingspan of any airplane ever built. It is now preserved at the Evergreen Aviation Museum in McMinnville, Oregon.